江仲平 医学博士 副教授 博士/硕士生导师 海南省高层次“D类人才”

  邮箱：zpjiang@hainanu.edu.cn

  1.教育背景

  2019.07-2021.07  南方医科大学        药物化学  博士后

  2013.09-2019.06  暨南大学（硕博连读）   中药化学  博士

  2009.09-2013.06  湖北中医药大学       制药工程  学士

  2.教学情况

 海洋药物学、高等天然药物化学、有机波谱分析和药用植物学等课程教学

  3.科研情况

  长期致力于海洋天然药物研究；聚焦在热带海洋微生物，进行其资源库构建，并从中高效、深度挖掘具有抗神经退行性疾病、代谢性疾病和抗病毒活性的药物先导化合物。近些年，在Chemical Science, Organic Chemistry Frontiers, Chinese Journal of Chemistry和Phytochemistry等天然药物化学主流期刊发表SCI论文20余篇，期中一作/通讯论文10余篇；主持国家自然科学基金青年项目、地区项目和海南省自然科学基金面上等科研项目；担任CJNM、Fitoterapia等多个SCI杂志审稿人。

4.研究领域

1) 新颖活性海洋天然产物的发现和复杂化合物的结构鉴定

2) 活性天然产物的结构修饰、作用机制与靶标研究

5.代表性科研项目

1) 国家自然科学基金地区项目（82460696）：靶向调控神经炎症的海洋真菌倍半萜内酯类化合物高效挖掘与抗阿尔兹海默病研究，2025.01～2028.12，主持

2) 国家自然科学基金青年项目（82204275）：红树植物海漆来源的甘遂烷型FXR激动剂发现、结构优化及其抗NASH活性研究，2023.01～2025.12，主持

3) 海南省自然科学基金面上项目（323MS014），2023.03～2026.02，主持

6.代表性成果

1) Z. P. Jiang,^# S. H. Sun,^# Y. Yu, A. Mándi, J. Y. Luo, M. H. Yang, T. Kurtán,* W. H. Chen,* L. Shen,* and J. Wu.* Discovery of benthol A and its challenging stereochemical assignment: opening up a new window for skeletal diversity of super-carbon-chain compounds. Chem. Sci. 2021, 12, 10197–10206. (IF = 9.825, 中科院一区，Hot off the Press)

2) Z. P. Jiang,^# M. T. Chen,^# X. Xiang, C. J. Xu, Y. Rao, H. Z. Du,* W. S. Li,* L. Huang.* Eutypetides A—E, Structurally Intriguing Polyketides Formed by Intramolecular [4+2] Cycloaddition from Marine-Derived Fungus Eutypella sp. F0219. Chin. J. Chem. 2025, 43, 23—32. (中科院一区，内封面论文)

3) Z. P. Jiang,^# R. Su,^# M. T. Chen, J. Y. Li, H. Y. Chen, L. Yang, F. F. Liu, J. Liu, C. J. Xu, W. S. Li,* Y. Rao,* L. Huang,* Ent-eudesmane sesquiterpenoids with anti-neuroinflammatory activity from the marine-derived fungus Eutypella sp. F0219. Phytochemistry 2024, 223, 114121. (中科院二区)

4) C. Y. Wu,^# Y. Chen,^# M. T. Chen, T. T. Fu, J. Liu, F. F. Liu, C. J. Xu, W. S. Li, B. L. Li, Z. P. Jiang,* Y. Rao,* L. Huang.* Natural linoleic acid from marine fungus Eutypella sp. F0219 blocks KEAP1/NRF2 interaction and ameliorates MASLD by targeting FABP4. Free Radic. Biol. Med. 224 (2024) 630–643. (中科院二区Top)

5) J. Y. Li,^# L. Yang,^# M. B, Chen, Y. Rao, Z. P. Jiang,* L. Huang,* Diterpenoids from Mangrove Plant Excoecaria agallocha L. and Their Anti-neuroinflammatory Activities. Chin. J. Org. Chem. 2024, 44, xxxx～xxxx, DOI: 10.6023/cjoc202404024.

6) W. S. Li,^# X. P. Lei,^# X. T. Yan, Y. Y. Qin, G. Y. Chen, S. Li,* Z. P. Jiang,* Hainanxylogranolides A–F: New Limonoids isolated from the seeds of Hainan mangrove plant Xylocarpus granatum. Fitoterapia 165 (2023) 105407.

7) J. Wu,^#* Z. P. Jiang,^# R. J. Yan, S. H. Sun, Y. Yu, L. Shen,* Gibbosolide A, a highly functionalized 20-membered macrolide with a terminal cis-fused 2-methylhexahydro-2H-furo[3,2-b]pyran motif: insights into late-stage cyclization of marine macrolides. Org. Chem. Front. 2021, 8, 5756–5765. (中科院一区)

8) Z. P. Jiang, Y. Yu, L. Shen.* Agallolides A-M, including two rearranged ent-atisanes featuring a bicyclo[3.2.1]octane motif, from the Chinese Excoecaria agallocha. Bioorg. Chem. 2020, 104: 104206. (中科院二区Top)

9) Z. P. Jiang^#, Z. L. Luan^#, R. X. Liu, Q. Zhang, X. C. Ma, L. Shen,* J. Wu.* Mangrove Tirucallane-and Apotirucallane-Type Triterpenoids: Structure Diversity of the C-17 Side-Chain and Natural Agonists of Human Farnesoid/Pregnane–X–Receptor. Mar. Drugs. 2018, 16(12), 488. (中科院二区)

10) Z. P. Jiang, B. H. Zou, X. J. Li, J. J. Liu, L. Shen,* J. Wu.* Ent-kauranes from the Chinese Excoecaria agallocha L. and NF-κB inhibitory activity. Fitoterapia 2019, 133, 159–170.

11) Z. P. Jiang, L. W. Tian, L. Shen,* J. Wu.* Ent-abietanes from the Godavari mangrove, Ceriops decandra: Absolute configuration and NF-κB inhibitory activity. Fitoterapia 2018, 130, 272–280.

欢迎具有药学、化学、生物学背景，对海洋天然药物化学满怀热情的同学报考本课题组研究生。